More flavour up front

Triage up front.

OBJECTIVES To assess the effectiveness of a newly developed triage tool to provide urgent access to genitourinary medicine (GUM) for patients. To appraise its value in compiling statistics for patients attending the department without appointments or those telephoning for advice. METHOD Retrospective evaluation of triage forms completed by healthcare professional (HCP). Randomly selected tria...

Pharmaceutical Up-Front Licensing Fees

Alemtuzumab in the up-front setting

Alemtuzumab is a humanized chimeric monoclonal antibody targeting CD52. Although this agent already has an important role in the treatment of chronic lymphocytic leukemia (CLL), many of its uses are still being defined. Early trials showed alemtuzumab's value in refractory disease and helped to define its excellent activity in the bone marrow, spleen and 17p deleted patients. The CAM307 trial h...

Therapeutic innovation: the up-front window.

The cure of cancer with chemotherapy has generally required three or more agents used in combination. The cure rate of ALL’ in children has progressively increased to 80%, partially as a result of a current total of nine agents (1). The agents individually have definite, albeit limited, activity, but rarely are single agents capable of cure. The good news is that such agents are being discovere...

KPP Pulsating Front Speed-up by Flows

We obtain a criterion for pulsating front speed-up by general periodic incompressible flows in two dimensions and in the presence of KPP nonlinearities. We achieve this by showing that the ratio of the minimal front speed and the effective diffusivity of the flow is bounded away from zero and infinity by constants independent of the flow. We also study speed-up of reaction-diffusion fronts by v...